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It has   been validated for the accuracy of prescription claims.43 It also contains information on vital status.44The study groups consisted of patients exclusively given one or more prescriptions for celecoxib, rofecoxib, or any non selective NSAID after the index admission.
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The early benefit obtained with combination of streptokinase and one month of aspirin also seemed to persist long term.s: The early survival advantages produced by fibrinolytic therapy and one month of aspirin started in acute myocardial infarction seem to be maintained for at least 10 years.Key messagesLarge randomised trials have shown that the survival benefits of intravenous fibrinolytic therapy for patients with acute myocardial infarction persist for at least one year, but there is relatively little information about longer term effectsBy contrast, this report from the ISIS 2 trial of intravenous streptokinase and of one month of oral aspirin !include!s nearly 4000 deaths between the start of year 2 and the end of year 10The early survival benefits of fibrinolytic therapy persist for at least 10 years after treatment and do not seem to increase or decrease with prolonged follow up in any category of patients, including elderly subjectsThe survival benefits of short term aspirin treatment in acute myocardial infarction also persist long term and are additional to those of fibrinolytic therapy, and other studies show that these benefits can be increased by continuing aspirin treatment for some years after myocardial infarctionThe second international study of infarct survival (ISIS 2) in 17 187 patients with suspected acute myocardial infarction,1 together with the other large randomised trials,2 9 showed unequivocally that, in suitable patients, fibrinolytic therapy reduces early mortality.
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